SS-31 (Elamipretide)

SS-31 is a mitochondria-targeted tetrapeptide that binds cardiolipin on the inner mitochondrial membrane. Optimizes electron transport chain function and reduces oxidative stress at its source for aging and mitochondrial research.

SS-31 (Elamipretide, also designated Bendavia and MTP-131) is a cell-permeable, mitochondria-targeted tetrapeptide with the sequence D-Arg-2′,6′-dimethyltyrosine (Dmt)-Lys-Phe-NH₂. The peptide was designed with an alternating aromatic-cationic motif (aromatic-cationic-aromatic-cationic) that enables selective accumulation in the inner mitochondrial membrane (IMM), driven by the mitochondrial membrane potential (ΔΨm). This targeting achieves over 1,000-fold concentration in mitochondria relative to the extracellular space — making SS-31 one of the most efficiently targeted subcellular delivery molecules in peptide chemistry.

The molecular target of SS-31 is cardiolipin, a unique diphosphatidylglycerol phospholipid found exclusively in the inner mitochondrial membrane. Cardiolipin plays essential structural roles: it anchors and stabilizes electron transport chain (ETC) complexes I, III, IV, and V, stabilizes the supercomplex (respirasome) organization that enables efficient substrate channeling, and maintains the association of cytochrome c with the IMM surface necessary for electron transfer from Complex III to Complex IV. By binding to cardiolipin, SS-31 stabilizes these protein-lipid interactions, optimizing electron transfer efficiency, reducing electron leak to molecular oxygen (the source of mitochondrial superoxide), and preserving cristae ultrastructure.

Published research spans multiple disease-relevant paradigms: cardiac ischemia-reperfusion injury (cardioprotection), acute kidney injury (renal mitochondrial rescue), skeletal muscle aging (reversal of age-related mitochondrial dysfunction), heart failure (improved cardiac energetics), Barth syndrome research (cardiolipin remodeling deficiency), and neurodegenerative models. Notably, aged skeletal muscle treated with SS-31 demonstrates reversal of mitochondrial dysfunction markers to near-youthful levels in published studies.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For mitochondrial biology and aging research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.