KissPeptin-10

KissPeptin-10 is the minimal active fragment of the Kisspeptin system — the master gatekeeper of GnRH neuron activation. A potent KISS1R (GPR54) agonist for reproductive axis and puberty onset research.

KissPeptin-10 (Metastin 45-54) is the shortest fully bioactive fragment of the Kisspeptin family, comprising the C-terminal 10 amino acids of the KISS1 gene product. The Kisspeptin system was identified through a convergence of cancer biology and reproductive genetics: the KISS1 gene was originally discovered as a metastasis suppressor in melanoma, while loss-of-function mutations in its receptor GPR54 (now KISS1R) were independently identified as the cause of idiopathic hypogonadotropic hypogonadism (IHH) in consanguineous families. This receptor-disease linkage established Kisspeptin/KISS1R as the primary upstream activator of the reproductive hormone axis.

KissPeptin-10 is a full agonist at KISS1R (GPR54), a Gq/11-coupled GPCR expressed on hypothalamic GnRH neurons. KISS1R activation triggers phospholipase C, IP3-mediated calcium release, and PKC activation, which depolarize GnRH neurons and stimulate pulsatile gonadotropin-releasing hormone (GnRH) secretion into the hypophyseal portal vasculature. GnRH in turn drives pituitary LH and FSH release, which activate gonadal function. Kisspeptin neurons in the arcuate nucleus (KNDy neurons: Kisspeptin/Neurokinin B/Dynorphin) are now recognized as the hypothalamic GnRH pulse generator, making KISS1R the ultimate upstream switch for reproductive axis activation.

Research applications include puberty onset mechanisms, GnRH pulse generator physiology, sex steroid feedback integration (estrogen and testosterone modulate Kisspeptin neuron activity as the feedback node), hypothalamic-pituitary-gonadal (HPG) axis regulation, seasonal breeding biology, and metabolic-reproductive interface studies (Kisspeptin neurons integrate metabolic signals from leptin and insulin to gate reproductive function).

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For reproductive neuroendocrinology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.