Snap-8 (Acetyl Octapeptide-3)

Snap-8 is a SNARE complex-targeting octapeptide that competes with SNAP-25 to modulate vesicle fusion at neuromuscular junctions. An extended Argireline analog for cosmetic neuroscience and signal peptide research.

Snap-8 (Acetyl Octapeptide-3) is a biomimetic peptide comprising eight amino acids with N-terminal acetylation, designed to interfere with SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor) complex assembly. The SNARE complex — formed by syntaxin, SNAP-25, and VAMP/synaptobrevin — is the molecular machinery responsible for synaptic vesicle fusion and neurotransmitter release at neuromuscular junctions. Snap-8 competes with endogenous SNAP-25 for incorporation into this trimeric complex, producing an improperly assembled complex with reduced fusogenic activity.

Snap-8 is an extended eight-amino-acid version of Acetyl Hexapeptide-3 (Argireline), one of the most commercially successful cosmetic peptides. The two additional residues provide improved competitive binding stability and enhanced resistance to exopeptidase degradation in cell culture models. Unlike botulinum neurotoxins, which irreversibly cleave SNARE proteins via zinc-dependent endopeptidase activity, Snap-8’s mechanism is competitive and fully reversible — it does not destroy SNARE components but rather prevents their proper assembly. This non-enzymatic, non-toxic mechanism makes it a valuable research tool for studying vesicle fusion dynamics without permanent synaptic disruption.

Research applications include neuromuscular junction biology, vesicle trafficking and membrane fusion mechanisms, cosmetic peptide efficacy research, catecholamine release modulation (chromaffin cell models), and comparative studies of SNARE complex interference strategies. Published data demonstrate concentration-dependent inhibition of catecholamine release from neuroendocrine cells.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For neuroscience and cosmetic peptide research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

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