HCG (Human Chorionic Gonadotropin)

HCG is a glycoprotein hormone with LH receptor agonist activity. The gold-standard research tool for studying gonadal steroidogenesis, Leydig cell function, and reproductive endocrinology.

Human Chorionic Gonadotropin (HCG) is a heterodimeric glycoprotein hormone consisting of a 92-amino acid alpha subunit (shared with LH, FSH, and TSH) and a 145-amino acid beta subunit unique to HCG that confers receptor specificity. The molecule is heavily glycosylated, with carbohydrate moieties comprising approximately 30% of its molecular mass, contributing to its extended biological half-life in research systems compared to the structurally related luteinizing hormone (LH).

HCG binds to and activates the luteinizing hormone/chorionic gonadotropin receptor (LHCGR), a G-protein coupled receptor (GPCR) expressed predominantly in gonadal tissue. In Leydig cells (testicular interstitial cells), LHCGR activation stimulates cAMP/PKA signaling that drives cholesterol transport into mitochondria via StAR (steroidogenic acute regulatory) protein, initiating the steroidogenic cascade that converts cholesterol to testosterone through sequential enzymatic steps (CYP11A1, CYP17A1, HSD3B, HSD17B). In ovarian tissue, LHCGR activation drives theca cell androgen production, corpus luteum maintenance, and progesterone synthesis. The longer half-life and greater receptor affinity of HCG compared to LH make it the preferred tool in gonadal function research.

Research applications include Leydig cell steroidogenesis studies, ovarian follicular dynamics, corpus luteum biology, gonadotropin receptor pharmacology, and reproductive endocrinology. HCG stimulation tests are used in research settings to assess gonadal steroidogenic capacity, with the magnitude of testosterone response serving as a functional readout of Leydig cell mass and enzymatic competence.

Supplied as a lyophilized powder with standardized biological activity measured in International Units (IU). Store at 2-8°C. For reproductive biology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.