Mazdutide

Mazdutide is a dual GLP-1/glucagon receptor agonist combining incretin and glucagon signaling for metabolic research. Enables study of concurrent appetite suppression and hepatic fat oxidation pathways.

Mazdutide (development codes LY3305677 / IBI362) is a synthetic dual-agonist peptide targeting both glucagon-like peptide-1 (GLP-1) and glucagon receptors simultaneously. Developed through a collaboration between Eli Lilly and Innovent Biologics, Mazdutide is engineered with fatty acid acylation for extended pharmacokinetic duration in research models. This dual-agonist design enables investigation of a metabolic research paradigm distinct from selective GLP-1 agonists or GLP-1/GIP dual agonists.

The rationale for dual GLP-1/glucagon co-agonism is grounded in complementary metabolic biology. GLP-1 receptor activation drives appetite suppression through hypothalamic signaling, delays gastric emptying, and enhances glucose-dependent insulin secretion from pancreatic beta cells. Glucagon receptor activation, traditionally viewed as a counter-regulatory signal, drives hepatic glycogenolysis but also — critically for metabolic research — potently stimulates hepatic fatty acid beta-oxidation, increases energy expenditure through thermogenic mechanisms, and promotes amino acid catabolism. The combination enables simultaneous investigation of centrally-mediated appetite reduction with peripherally-mediated energy expenditure enhancement.

Published preclinical data demonstrate that the dual agonist approach produces greater body weight reduction and hepatic triglyceride clearance than either receptor agonist alone in research models. This has positioned Mazdutide as a compound of particular interest in MASH/NAFLD (metabolic dysfunction-associated steatohepatitis / non-alcoholic fatty liver disease) research, where hepatic lipid accumulation is the primary pathological feature. The glucagon-driven hepatic fat oxidation component directly addresses liver fat in a way that GLP-1-selective compounds do not.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For metabolic and endocrinology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.