VIP (Vasoactive Intestinal Peptide)

VIP is a 28-amino acid neuropeptide and potent endogenous anti-inflammatory mediator. Signals via VPAC1/VPAC2 receptors across neuroimmune, airway, circadian, and gastrointestinal research domains.

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid linear neuropeptide belonging to the secretin/glucagon/PACAP peptide superfamily, widely distributed throughout the central and peripheral nervous systems, immune cells (particularly T cells and macrophages), and the gastrointestinal tract. Originally discovered by Said and Mutt in 1970 as a vasodilatory substance from porcine intestine, VIP is now recognized as one of the most important endogenous neuroimmune mediators, with research applications spanning far beyond its original vascular characterization.

VIP signals through two G-protein coupled receptors: VPAC1 (widely expressed on immune cells, epithelial cells, and brain) and VPAC2 (predominantly expressed in CNS, smooth muscle, and immune cells). Both receptors couple to Gs and stimulate adenylyl cyclase, elevating cAMP and activating PKA/CREB signaling. As an anti-inflammatory mediator, VIP potently suppresses macrophage and microglial activation, inhibiting production of TNF-α, IL-6, IL-12, iNOS, and COX-2. It promotes regulatory T-cell (Treg) differentiation, drives Th2 polarization, and maintains mucosal immune tolerance in the gut-associated lymphoid tissue (GALT). These immunomodulatory properties have made VIP one of the most studied peptides in inflammatory and autoimmune disease research models.

Additional research domains include airway biology (VIP is a primary non-adrenergic, non-cholinergic bronchodilator), circadian rhythm regulation (VPAC2 is the dominant receptor on SCN clock neurons, required for circadian pacemaker function), neuroprotection (VIP protects hippocampal and cortical neurons against excitotoxicity and oxidative damage), and intestinal physiology (regulation of electrolyte secretion, mucosal blood flow, and intestinal motility). VIP-knockout and VPAC-receptor-knockout animal models have provided extensive loss-of-function data validating these research applications.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. Reconstitute in sterile water or 0.1% acetic acid. For neuroimmunology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.