Cagrilintide

Cagrilintide is a long-acting acylated amylin receptor agonist designed for metabolic research. Targets AMY1/2/3 receptors to study satiety signaling and energy homeostasis pathways.

Cagrilintide is a synthetic long-acting analog of human amylin, a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells in response to nutrient intake. The endogenous amylin peptide plays complementary roles to insulin in glucose homeostasis — it slows gastric emptying, suppresses post-prandial glucagon secretion, and promotes satiety through action on area postrema neurons in the brainstem. Cagrilintide was engineered with specific amino acid modifications and C18 fatty diacid acylation to dramatically extend its pharmacokinetic profile in research models, overcoming the rapid degradation and aggregation tendencies that limit the utility of native amylin in experimental settings.

The peptide activates amylin receptors, which are heterodimeric complexes formed by the calcitonin receptor (CTR) co-expressed with receptor activity-modifying proteins (RAMPs): AMY1 (CTR+RAMP1), AMY2 (CTR+RAMP2), and AMY3 (CTR+RAMP3). These receptors are densely expressed in the area postrema and nucleus tractus solitarius of the brainstem, where they transduce satiety signals that reduce food intake. Cagrilintide also retains activity at the calcitonin receptor itself. Intracellular signaling downstream of amylin receptor activation involves cAMP/PKA and ERK1/2 cascades, ultimately modulating hypothalamic neuropeptide expression including suppression of orexigenic (appetite-stimulating) pathways.

Research interest in Cagrilintide has intensified due to published data demonstrating synergistic metabolic effects when studied alongside GLP-1 receptor agonists — a dual-pathway approach that targets two independent satiety signaling nodes. While GLP-1 agonists primarily act on hypothalamic GLP-1R-expressing neurons and pancreatic beta cells, amylin agonists primarily engage brainstem circuits, creating an opportunity for complementary rather than redundant signaling. This dual amylin/GLP-1 paradigm represents a next-generation approach in metabolic research and is the basis for combination formulations currently under investigation.

Supplied as a lyophilized powder with ≥99% purity confirmed by RP-HPLC and ESI-MS. Store at -20°C desiccated. For metabolic and endocrinology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.