HMG is a purified gonadotropin preparation providing both FSH and LH activity. The standard dual-gonadotropin tool for studying folliculogenesis, spermatogenesis, and coordinated reproductive signaling.
Human Menopausal Gonadotropin (HMG) is a purified preparation providing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity in standardized ratios. The dual-gonadotropin composition enables research into the coordinated, synergistic roles of FSH and LH in reproductive biology — a research question that cannot be adequately addressed with either hormone alone.
FSH acts primarily through the FSH receptor (FSHR, Gs-coupled GPCR) on granulosa cells (ovary) and Sertoli cells (testis), driving follicular development, aromatase expression, inhibin production, and spermatogenic support. LH acts through the LHCGR on theca cells and Leydig cells, driving androgen production that serves as the aromatase substrate for estrogen synthesis and independently maintaining steroidogenic output. The two-cell, two-gonadotropin model of ovarian function — in which LH-driven theca cell androgens are converted to estrogens by FSH-stimulated granulosa cell aromatase — can only be fully studied with preparations providing both activities.
Research applications include folliculogenesis dynamics, oocyte maturation studies, spermatogenesis support, gonadotropin receptor cross-talk investigation, and reproductive endocrinology. The 75 IU per vial standardization provides consistent dosing for research protocols.
Supplied as a lyophilized powder with standardized FSH and LH activity. Store at 2-8°C. For reproductive endocrinology research only.
HMG (Human Menopausal Gonadotropin)
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