GHRP-6 Acetate

GHRP-6 is a first-generation synthetic hexapeptide ghrelin receptor (GHS-R1a) agonist. One of the earliest GH secretagogues discovered, studied for GH release, appetite signaling, and gastric motility research.

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂, identified through systematic screening of Met-enkephalin derivatives by Bowers and Momany in the 1980s. It was one of the earliest synthetic growth hormone secretagogues (GHS) discovered, predating the identification of the endogenous ligand ghrelin by over a decade. This historical significance means GHRP-6 has accumulated an extensive body of published pharmacological data, making it a well-characterized reference compound for GH secretagogue research.

GHRP-6 functions as a potent agonist at the growth hormone secretagogue receptor type 1a (GHS-R1a), the same receptor subsequently identified as the target for endogenous ghrelin. GHS-R1a is a Gq/11-coupled GPCR that signals through phospholipase C, IP3 generation, and intracellular calcium mobilization in anterior pituitary somatotrophs. This calcium-dependent mechanism is distinct from and complementary to the cAMP/PKA pathway activated by GHRH, which is the molecular basis for the well-documented synergistic GH release observed when GHRP-6 and GHRH analogs are combined in research settings.

Unlike later-generation GH secretagogues such as Ipamorelin, GHRP-6 retains significant ghrelin-mimetic properties beyond GH release. Published research documents stimulation of appetite and food intake, acceleration of gastric motility, stimulation of cortisol and ACTH release, and mild prolactin elevation. These “off-target” effects from a GH-selective standpoint are actually valuable research features — they make GHRP-6 a useful tool for studying the broader physiological roles of ghrelin receptor activation, including gut-brain axis signaling, orexigenic pathways, and the relationship between appetite and GH secretion.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For endocrinology and GH axis research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.