CJC-1295 With DAC

CJC-1295 with DAC is a GHRH analog conjugated to Drug Affinity Complex technology for albumin binding. Produces sustained, non-pulsatile GH elevation for long-duration research protocols.

CJC-1295 with DAC (Drug Affinity Complex) is a modified GHRH analog that incorporates a maleimidopropionic acid (MPA) bioconjugation linker enabling covalent in situ binding to the Cys34 residue of circulating serum albumin. The base peptide contains the same tetrasubstituted GRF(1-29) sequence as the non-DAC version (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷-NH₂), with the DAC moiety attached via a lysine residue at position 30. The albumin conjugation dramatically extends the effective research half-life by reducing renal clearance and proteolytic degradation, creating a long-acting GHRH receptor agonist.

The pharmacokinetic distinction between the DAC and non-DAC forms has profound implications for GH axis research. While CJC-1295 without DAC produces brief, pulsatile GH release bursts, the DAC-conjugated form maintains sustained, non-pulsatile elevation of GH secretion over extended research periods. This creates a tonic GH stimulation pattern — fundamentally different from the episodic, ultradian GH secretion rhythm governed by alternating GHRH and somatostatin release from hypothalamic neurons. Researchers studying the consequences of tonic versus pulsatile GH exposure on target tissues (liver, muscle, adipose, bone) benefit from having both tools available for comparative experimental designs.

The DAC bioconjugation technology itself is an area of research interest in peptide engineering, as it represents an elegant approach to extending peptide half-life without PEGylation or Fc-fusion strategies. Published studies characterizing the CJC-1295/albumin complex have confirmed retention of full GHRHR agonist activity following albumin conjugation.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For endocrinology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.