Sermorelin Acetate

Sermorelin is native human GHRH(1-29) — the shortest fully active GHRH fragment with no amino acid modifications. The gold-standard reference peptide for GHRH receptor pharmacology and physiological GH release research.

Sermorelin Acetate (GRF 1-29 NH₂) is a synthetic peptide identical to the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-44), amidated at the C-terminus. Endogenous GHRH is a 44-amino acid peptide produced by arcuate nucleus neurons in the hypothalamus and released into the hypophyseal portal blood system to stimulate GH synthesis and secretion from anterior pituitary somatotrophs. Structure-activity studies established that the N-terminal 29 residues contain the complete receptor-binding and activation domain, with residues 30-44 serving primarily as a structural spacer that does not contribute to receptor affinity or efficacy.

Sermorelin maintains the native, unmodified human GHRH(1-29) sequence — it contains no D-amino acid substitutions, no acylation, and no bioconjugation. This makes it the reference standard for GHRH receptor (GHRHR) pharmacology research: it produces the most physiologically representative GHRH receptor activation available in a synthetic peptide. Sermorelin activates GHRHR (a class B GPCR on somatotrophs) through Gs-coupled adenylyl cyclase activation, cAMP elevation, and PKA-mediated GH gene transcription and granule exocytosis. The resulting GH release is pulsatile and subject to normal somatostatin feedback inhibition — distinguishing it from DAC-conjugated forms that produce tonic GH elevation.

Research applications include GH axis physiology, somatotroph cell biology, pituitary function assessment, age-related GH secretion decline (somatopause research), comparison studies with modified analogs (CJC-1295, Tesamorelin), and pediatric growth biology models. Sermorelin’s extensive clinical research history provides a large published reference dataset for correlating research findings with biological outcomes.

Supplied as an acetate salt in lyophilized form with ≥99% purity. Store at -20°C desiccated. For endocrinology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.