Selank

Selank is a Tuftsin analog with PGP stabilization — unique dual-action profile spanning immunomodulation and anxiolytic/nootropic research. Modulates BDNF, IL-6, enkephalins, and GABAergic signaling.

Selank (sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide designed by extending the endogenous immunostimulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg) with the same Pro-Gly-Pro (PGP) C-terminal stabilization motif used in Semax. Tuftsin is a naturally occurring peptide released by splenic enzymatic cleavage from the CH2 domain of the IgG heavy chain, primarily functioning as a phagocyte activator that stimulates monocyte and macrophage chemotaxis, phagocytosis, and microbicidal activity. The PGP extension provides resistance to aminopeptidases and carboxypeptidases, extending the effective research half-life.

What makes Selank unique among neuropeptide research tools is its dual immunomodulatory and anxiolytic/nootropic activity profile. On the immune side, published research documents modulation of IL-6, IFN-γ, and other cytokines, enhancement of phagocytic activity, and influence on T-cell function consistent with the parent Tuftsin activity. On the neurological side — which is unexpected for an IgG-derived peptide — Selank modulates GABAergic neurotransmission, influences the balance of GABA-A receptor subunit expression (particularly alpha and delta subunits), increases BDNF and enkephalin expression, and affects serotonin metabolism by modulating SERT (SLC6A4) expression. Gene expression profiling in hippocampal tissue models has identified over 50 differentially regulated genes following Selank exposure.

Research applications include neuroimmunology (immune-brain axis studies), anxiety and stress response paradigms, cognitive enhancement models, GABAergic pharmacology, and comparative studies with Semax (both peptides share the PGP motif but derive from different parent peptides and produce distinct biological profiles). The dual immune-neural activity profile makes Selank particularly relevant for research investigating the growing field of psychoneuroimmunology — the bidirectional communication between the immune system and the central nervous system.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For neuroscience and immunology research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.