Semax

Semax is a synthetic ACTH(4-10) analog with a PGP stability extension. Upregulates BDNF and NGF expression without adrenal activity — a premier neuroprotective and nootropic peptide for cognitive research.

Semax (sequence: Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the ACTH(4-10) fragment of adrenocorticotropic hormone. The ACTH(4-10) sequence (Met-Glu-His-Phe-Arg-Trp-Gly) was identified in early neuroendocrine research as the “behaviorally active” core of ACTH — it modulates attention, learning, and memory in animal paradigms while completely lacking the adrenal-stimulating (steroidogenic) activity of full-length ACTH, which requires the N-terminal 1-24 sequence for adrenal receptor activation. Semax replaces the C-terminal Arg-Trp-Gly with Pro-Gly-Pro (PGP), a tripeptide extension that confers resistance to both aminopeptidase and carboxypeptidase degradation, extending the biological half-life from minutes to hours.

The neurotrophic mechanism of Semax has been extensively characterized in published research. The peptide upregulates BDNF (brain-derived neurotrophic factor) mRNA and protein expression in hippocampal and cortical neurons through CREB-dependent transcription. BDNF/TrkB signaling promotes neuronal survival, synaptic plasticity, long-term potentiation (LTP), and dendritogenesis. Semax also increases NGF (nerve growth factor) expression and modulates serotonergic neurotransmission by influencing SERT (serotonin transporter) expression and tryptophan hydroxylase activity. Dopaminergic effects have been documented through modulation of D1/D2 receptor signaling in striatal and prefrontal regions. Gene expression profiling studies have identified broad transcriptional changes affecting neuroplasticity-related genes, immune-related genes, and vascular genes in brain tissue.

Research applications include cognitive enhancement paradigms (Morris water maze, novel object recognition, passive avoidance), neuroprotection models (cerebral ischemia, excitotoxicity, oxidative stress), neurodegenerative disease research (BDNF-deficiency models), attention and learning studies, and cerebrovascular research. Semax has been the subject of over 100 publications, primarily from the Institute of Molecular Genetics, Russian Academy of Sciences, with growing international research interest.

Supplied as a lyophilized powder with ≥99% purity. Store at -20°C desiccated. For neuroscience research only.

Product Specifications

Certificate of Analysis

Every batch ships with a Janoshik-verified COA covering HPLC purity, mass spectrometry confirmation, and batch traceability.

Shipping & Lead Times

• US warehouse: ships within 1–2 business days · estimated 3–5 day delivery
• HK warehouse: ships within 2–3 business days · estimated 7–14 day international delivery
• Carriers: DHL Express, FedEx International, UPS Worldwide
• Discreet outer packaging — no peptide branding visible
• Tracking number emailed on dispatch

Lost or Detained Packages

If your shipment is lost or detained by customs, we will reship once free of charge. Contact us with your order number.